Every few months, a new study about the effects of smoking e-cigarettes concludes the opposite of whatever came before it. It’s a cycle that started when the popularity for the cigarette alternatives exploded a few years ago and has led to a lot of confusion over whether vaping is bad for your health.

We have, over the decades, mostly come to a consensus on the dangers of smoking combustible cigarettes—a conclusion founded on countless long-term studies. Until now, e-cigarette studies have simply either analyzed the product or investigated the effects on animal and cell models.

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